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Article

Activation of bacterial channel MscL in mechanically stimulated droplet interface bilayers.

Scientific reports - 8 Sept 2015

Najem Joseph S, Dunlap Myles D, Rowe Ian D, Freeman Eric C, Grant John W, Sukharev Sergei, Leo Donald J

Abstract excerpt

MscL, a stretch-activated channel, saves bacteria experiencing hypo-osmotic shocks from lysis. Its high conductance and controllable activation makes it a strong candidate to serve as a transducer in stimuli-responsive biomolecular materials. Droplet interface bilayers (DIBs), flexible insulating scaffolds for such materials, can be used as a new platform for incorporation and activation of MscL. Here, we report...

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Identifiers

PMID: 26348441
DOI: 10.1038/srep13726
PMCID: PMC4562232

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