Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels.

Abstract excerpt

OSCA/TMEM63 channels, which have transporter-like architectures, are bona fide mechanosensitive (MS) ion channels that sense high-threshold mechanical forces in eukaryotic cells. The activation mechanism of these transporter-like channels is not fully understood. Here we report cryo-EM structures of a dimeric OSCA/TMEM63 pore mutant OSCA1.1-F516A with a sequentially extracellular dilated pore in a detergent...

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• Cryoelectron Microscopy
• HEK293 Cells
• Ion Channels
• Mechanotransduction, Cellular
• Membrane Proteins