Article
Activation of the mechanosensitive ion channel MscL by mechanical stimulation of supported Droplet-Hydrogel bilayers.
Scientific reports - 27 Mar 2017
Rosholm Kadla R, Baker Matthew A B, Ridone Pietro, Nakayama Yoshitaka, Rohde Paul R, Cuello Luis G, Lee Lawrence K, Martinac Boris
Abstract excerpt
The droplet on hydrogel bilayer (DHB) is a novel platform for investigating the function of ion channels. Advantages of this setup include tight control of all bilayer components, which is compelling for the investigation of mechanosensitive (MS) ion channels, since they are highly sensitive to their lipid environment. However, the activation of MS ion channels in planar supported lipid bilayers, such as the DHB,...
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