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Article

The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry.

The Journal of cell biology - 14 Sept 2015

von Büdingen H-Christian, Mei Feng, Greenfield Ariele, Jahn Sarah, Shen Yun-An A, Reid Hugh H, McKemy David D, Chan Jonah R

Abstract excerpt

Myelin oligodendrocyte glycoprotein (MOG) is a central nervous system myelin-specific molecule expressed on the outer lamellae of myelin. To date, the exact function of MOG has remained unknown, with MOG knockout mice displaying normal myelin ultrastructure and no apparent specific phenotype. In this paper, we identify nerve growth factor (NGF) as a binding partner for MOG and demonstrate that this interaction is...

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Source

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Identifiers

PMID: 26347141
DOI: 10.1083/jcb.201504106
PMCID: PMC4576870

Genes

MOG
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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