Article
p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.
Nature neuroscience - 1 May 2010
Park Katya J, Grosso Carlos Ayala, Aubert Isabelle, Kaplan David R, Miller Freda D
Abstract excerpt
Axonal degeneration is important during development but has not been thought to function in the intact mature nervous system. Here, we provide evidence that degeneration of adult axons occurs in the intact rodent brain through a p75 neurotrophin receptor (p75NTR)- and myelin-dependent mechanism. Specifically, we show that p75NTR-mediated axonal degeneration prevents septal cholinergic axons from aberrantly...
Topics
- Animals
- Axons
- Caspase 6
- Cells, Cultured
- Choline O-Acetyltransferase
- Cofilin 1
- Cyclic AMP
- Dose-Response Relationship, Drug
- Embryo, Mammalian
- Enzyme Inhibitors
- Gene Expression Regulation
- Green Fluorescent Proteins
- Mice
- Mice, Inbred C57BL