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Article

MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 May 2010

Cafferty William B J, Duffy Philip, Huebner Eric, Strittmatter Stephen M

Abstract excerpt

Functional recovery after adult CNS damage is limited in part by myelin inhibitors of axonal regrowth. Three molecules, Nogo-A, MAG, and OMgp, are produced by oligodendrocytes and share neuronal receptor mechanisms through NgR1 and PirB. While each has an axon-inhibitory role in vitro, their in vivo interactions and relative potencies have not been defined. Here, we compared mice singly, doubly, or triply mutant...

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Source

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Identifiers

PMID: 20484625
DOI: 10.1523/JNEUROSCI.6239-09.2010
PMCID: PMC2883258

Genes

MAG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma.PMID 20484625Read ↗

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No Nogo: now where to go?Semantic proximity Read ↗

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The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry.Semantic proximity Read ↗

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LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.Semantic proximity Read ↗

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