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Article

The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho.

The Journal of cell biology - 13 May 2002

Yamashita Toshihide, Higuchi Haruhisa, Tohyama Masaya

Abstract excerpt

Myelin-associated glycoprotein (MAG) is a potent inhibitor of neurite outgrowth from a variety of neurons. The receptor for MAG or signals that elicit morphological changes in neurons remained to be established. Here we show that the neurotrophin receptor p75 (p75(NTR)) is the signal transducing element for MAG. Adult dorsal root ganglion neurons or postnatal cerebellar neurons from mice carrying a mutation in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12011108
DOI: 10.1083/jcb.200202010
PMCID: PMC2173856

Genes

MAG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho.PMID 12011108Read ↗

MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma.Semantic proximity Read ↗

The p75 receptor mediates axon growth inhibition through an association with PIR-B.Semantic proximity Read ↗

Myelination and axonal regeneration in the central nervous system of mice deficient in the myelin-associated glycoprotein.Semantic proximity Read ↗

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA.Semantic proximity Read ↗

Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.Semantic proximity Read ↗

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.Semantic proximity Read ↗

p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping.Semantic proximity Read ↗

The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry.Semantic proximity Read ↗

Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.Semantic proximity Read ↗

Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology.Semantic proximity Read ↗

Integrin Signaling in Oligodendrocytes and Its Importance in CNS MyelinationSemantic proximity Read ↗

Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord.Semantic proximity Read ↗

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