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Nerve growth factor: what can surgeons and oncologists learn from a neurological and psychological biomarker?

9 Aug 2025

Abstract excerpt

BACKGROUND: As the first discovered member of the neurotrophin family, nerve growth factor (NGF) plays fundamental roles in peripheral sensory and sympathetic neuronal development and survival. Recent evidence reveals its tumour-promoting effects through increasing perineural invasion, which is correlated with poor clinical outcomes. The exact molecular mechanisms exhibit malignancy-specific differences and...

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PMID: 40783715
DOI: 10.1186/s10020-025-01333-z

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