Article
The p75 receptor mediates axon growth inhibition through an association with PIR-B.
Cell death & disease - 1 Sept 2011
Fujita Y, Takashima R, Endo S, Takai T, Yamashita T
Abstract excerpt
The Nogo receptor and paired immunoglobulin-like receptor B (PIR-B) are receptors for three myelin-derived axon-growth inhibitors, including myelin-associated glycoprotein (MAG). In this study, we report that the p75 receptor is required for the signal transduction of PIR-B, which interacted with p75 upon ligand binding. In addition, p75 was required for activation of Src homology 2-containing protein tyrosine...
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