Article
Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury.
Neuron - 24 Apr 2003
Simonen Marjo, Pedersen Vera, Weinmann Oliver, Schnell Lisa, Buss Armin, Ledermann Birgit, Christ Franziska, Sansig Gilles, van der Putten Herman, Schwab Martin E
Abstract excerpt
To investigate the role of the myelin-associated protein Nogo-A on axon sprouting and regeneration in the adult central nervous system (CNS), we generated Nogo-A-deficient mice. Nogo-A knockout (KO) mice were viable, fertile, and not obviously afflicted by major developmental or neurological disturbances. The shorter splice form Nogo-B was strongly upregulated in the CNS. The inhibitory effect of spinal cord...
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