Article
Association of TLR2 and TLR4 non-missense single nucleotide polymorphisms with type 2 diabetes risk in a southern Chinese population: a case-control study.
Genetics and molecular research : GMR - 31 Jul 2015
Huang W H, Nie L H, Zhang L J, Jing L P, Dong F, Wang M, Zhang N, Liu Y, Zhang B H, Chen C, Lin H S, Wei X C, Yang G, Jing C X
Abstract excerpt
Toll-like receptors (TLRs), the triggers of the innate and adaptive immune responses, are involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Several studies have investigated the effects of genetic polymorphisms in TLR4 and TLR2, but they have yielded limited results. We investigated whether non-missense genetic polymorphisms in the regulatory regions of TLR4 and TLR2 were related to T2DM in a...
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