Article
Rarity of TLR4 Asp299Gly and Thr399Ile polymorphisms in the Korean population.
Yonsei medical journal - 29 Feb 2008
Kim Yeun Sun, Hwang You Jin, Kim Sung Yong, Yang Sun Mee, Lee Ki Young, Park Ie Byung
Abstract excerpt
PURPOSE: Activation of the innate immune system and chronic low-grade inflammation are thought to be involved in the pathogenesis of atherosclerosis and also thought to be associated with type 2 diabetes and its complications. As a receptor for bacterial lipopolysaccharide and heat-shock proteins, Toll-like receptor 4 (TLR4) is one of the central regulators of the immune response. Recent studies have reported an...
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