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Article

Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort.

PloS one - 1 Jan 2015

Li Yuqing, Beckman Kenneth B, Caberto Christian, Kazma Remi, Lum-Jones Annette, Haiman Christopher A, Le Marchand Loïc, Stram Daniel O, Saxena Richa, Cheng Iona

Abstract excerpt

The mitochondrial genome encodes for the synthesis of 13 proteins that are essential for the oxidative phosphorylation (OXPHOS) system. Inherited variation in mitochondrial genes may influence cancer development through changes in mitochondrial proteins, altering the OXPHOS process, and promoting the production of reactive oxidative species. To investigate the role of the OXPHOS pathway and mitochondrial genes in...

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Identifiers

PMID: 26340450
DOI: 10.1371/journal.pone.0136796
PMCID: PMC4560485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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