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Article

Inherited common variants in mitochondrial DNA and invasive serous epithelial ovarian cancer risk.

BMC research notes - 22 Oct 2013

Earp Madalene A, Brooks-Wilson Angela, Cook Linda, Le Nhu

Abstract excerpt

BACKGROUND: Mitochondria are the site of oxidative phosphorylation, a process which generates reactive oxygen species (ROS). Elevated ROS levels can lead to oxidative stress, a cellular state implicated in carcinogenesis. It is hypothesized that alternations in mitochondrial (MT) DNA, including heritable MT single nucleotide polymorphisms (MT-SNPs), have the potential to change the capacity of MT function,...

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PMID: 24148579
DOI: 10.1186/1756-0500-6-425
PMCID: PMC3854008

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