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Article

Ulcerative Colitis Is Under Dual (Mitochondrial and Nuclear) Genetic Control.

Inflammatory bowel diseases - 1 Apr 2016

Rosa Alexandra, Abrantes Patrícia, Sousa Inês, Francisco Vânia, Santos Patrícia, Francisco David, Xavier Joana M, Oliveira Sofia A

Abstract excerpt

BACKGROUND: Cellular oxidative stress and genetic susceptibility have been implicated in the multifactorial etiology of ulcerative colitis (UC). The nuclear genome association with UC has been intensely investigated, but the role of the mitochondrial DNA (mtDNA) has received far less attention and may account for part of the missing heritability. This study is a comprehensive analysis of the mtDNA contribution to...

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PMID: 26926037
DOI: 10.1097/MIB.0000000000000694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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