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Article

Mitochondrial related genome-wide Mendelian randomization identifies putatively causal genes for multiple cancer types.

EBioMedicine - 1 Feb 2023

Li Yanni, Sundquist Kristina, Zhang Naiqi, Wang Xiao, Sundquist Jan, Memon Ashfaque A

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction is a hallmark of cancer. However, it is unclear whether it is a cause of cancer. This two-sample Mendelian randomization (MR) analyses, uses genetic instruments to proxy the exposure of mitochondrial dysfunction and cancer summary statistics as outcomes, allowing for causal inferences. METHODS: Summary statistics from 18 common cancers (2107-491,974 participants), gene...

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Identifiers

PMID: 36634566
DOI: 10.1016/j.ebiom.2022.104432
PMCID: PMC9841346

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