Article
Metabolic disposition of ajmaline.
European journal of drug metabolism and pharmacokinetics - 1 Jan 2000
Köppel C, Tenczer J, Arndt I
Abstract excerpt
Urine was collected from six patients receiving a continuous infusion of 20 mg/h ajmaline. Pooled urine was extracted with and without enzymatic conjugate cleavage or hydrolysis with concentrated hydrochloric acid. The extracts were analyzed by gas chromatography/mass spectrometry. Ajmaline and its metabolites in urine were identified in the form of their acetylated derivatives. Twenty two different acetylated...
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