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Article

Metabolic disposition of ajmaline.

European journal of drug metabolism and pharmacokinetics - 1 Jan 2000

Köppel C, Tenczer J, Arndt I

Abstract excerpt

Urine was collected from six patients receiving a continuous infusion of 20 mg/h ajmaline. Pooled urine was extracted with and without enzymatic conjugate cleavage or hydrolysis with concentrated hydrochloric acid. The extracts were analyzed by gas chromatography/mass spectrometry. Ajmaline and its metabolites in urine were identified in the form of their acetylated derivatives. Twenty two different acetylated...

Topics

Ajmaline
Biotransformation
Chromatography, Thin Layer
Debrisoquin
Dextromethorphan
Drug Interactions
Gas Chromatography-Mass Spectrometry
Humans
Mass Spectrometry
Nifedipine
Phenotype
Quinidine

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Sparteine

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Identifiers

PMID: 2633926
DOI: 10.1007/BF03190117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2633926-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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