Article
Aminopyrine metabolism in man: the acetylation of aminoantipyrine cosegregates with acetylation of caffeine.
Therapeutic drug monitoring - 1 Feb 1995
Agúndez J A, Carrillo J A, Martínez C, Benítez J
Abstract excerpt
Aminopyrine and caffeine metabolism was evaluated in vivo in 21 healthy volunteers in order to elucidate whether the acetylation capacity of the two substances correlates. The ratio of the aminopyrine metabolites 4-acetylaminoantipyrine (AAA)/4-aminoantipyrine (AA) was compared with the ratios of caffeine metabolites AAMU/1-X and AAMU/(AAMU + 1-X + 1-U). All the subjects phenotyped as slow acetylators with...
Topics
- Acetylation
- Adult
- Aminopyrine
- Ampyrone
- Biotransformation
- Caffeine
- Dealkylation
- Female
- Humans
- Male
- Phenotype