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Article

Codeine O-demethylation: rat strain differences and the effects of inhibitors.

Biochemical pharmacology - 1 Mar 1991

Mikus G, Somogyi A A, Bochner F, Eichelbaum M

Abstract excerpt

The oxidative metabolism of more than 20 drugs (e.g. sparteine, debrisoquine, dextromethorphan) is mediated by cytochrome P450IID6. Codeine O-demethylation to morphine was recently demonstrated to co-segregate with the polymorphic metabolism of debrisoquine and dextromethorphan. The female Dark-Agouti rat (DA) is an animal model for the poor metabolizer phenotype (PM) using debrisoquine or dextromethorphan as...

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PMID: 1998530
DOI: 10.1016/0006-2952(91)90077-i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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