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Article

Codeine O-demethylation: rat strain differences and the effects of inhibitors.

Biochemical pharmacology - 1 Mar 1991

Mikus G, Somogyi A A, Bochner F, Eichelbaum M

Abstract excerpt

The oxidative metabolism of more than 20 drugs (e.g. sparteine, debrisoquine, dextromethorphan) is mediated by cytochrome P450IID6. Codeine O-demethylation to morphine was recently demonstrated to co-segregate with the polymorphic metabolism of debrisoquine and dextromethorphan. The female Dark-Agouti rat (DA) is an animal model for the poor metabolizer phenotype (PM) using debrisoquine or dextromethorphan as...

Topics

Animals
Codeine
Drug Interactions
Female
Kinetics
Methadone
Microsomes, Liver
Morphine
Oxidoreductases, O-Demethylating
Phenotype
Rats
Rats, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Salicylates

Salicylic Acid

Source

Identifiers

PMID: 1998530
DOI: 10.1016/0006-2952(91)90077-i

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1998530-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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