The metabolism of mexiletine in relation to the debrisoquine/sparteine-type polymorphism of drug oxidation.

doi:10.1111/j.1365-2125.1991.tb03931.x

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Article

The metabolism of mexiletine in relation to the debrisoquine/sparteine-type polymorphism of drug oxidation.

British journal of clinical pharmacology - 1 Oct 1991

Broly F, Vandamme N, Libersa C, Lhermitte M

Abstract excerpt

1. The relationship between the metabolism of the antiarrhythmic drug mexiletine and the debrisoquine/sparteine-type polymorphism was studied in vitro, using microsomes from six human livers, and in vivo, in nine healthy drug-free volunteers with wide variation in their ability to hydroxylate deb...

Topics

Adult
Debrisoquin
Female
Humans
Hydroxylation
Male
Mexiletine
Phenotype
Polymorphism, Genetic
Smoking
Sparteine

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