Adverse drug reaction reporting and retrospective phenotyping for oxidation polymorphism.

doi:10.1007/BF03259884

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Article

Adverse drug reaction reporting and retrospective phenotyping for oxidation polymorphism.

Medical toxicology and adverse drug experience - 1 Jan 2000

Clark D W, Edwards I R

Abstract excerpt

A genetically determined impairment in the ability to oxidase sparteine and debrisoquine also affects the oxidation of several other drugs. This impairment in oxidation may result in accumulation of the associated drugs and in an increased susceptibility to adverse reactions from these drugs. Dun...

Topics

Debrisoquin
Humans
Isoquinolines
Metoprolol
Nifedipine
Oxidation-Reduction
Phenotype
Piroxicam
Polymorphism, Genetic
Retrospective Studies
Sparteine

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