Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans.

doi:10.1016/0009-9236(95)90049-7

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Article

Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans.

Clinical pharmacology and therapeutics - 1 Oct 1995

Fromm M F, Hofmann U, Griese E U, Mikus G

Abstract excerpt

BACKGROUND: The opioid dihydrocodeine (DHC) is frequently used as an analgesic and antitussive agent. However, until now there have been no detailed data on dihydrocodeine metabolism in humans. We therefore investigated pathways that contribute to elimination of dihydrocodeine, and we tested the...

Topics

Adult
Codeine
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Dihydromorphine
Female
Gas Chromatography-Mass Spectrometry
Humans
Male
Metabolic Clearance Rate
Mixed Function Oxygenases
Phenotype
Sparteine

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