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Article

Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans.

Clinical pharmacology and therapeutics - 1 Oct 1995

Fromm M F, Hofmann U, Griese E U, Mikus G

Abstract excerpt

BACKGROUND: The opioid dihydrocodeine (DHC) is frequently used as an analgesic and antitussive agent. However, until now there have been no detailed data on dihydrocodeine metabolism in humans. We therefore investigated pathways that contribute to elimination of dihydrocodeine, and we tested the hypothesis that dihydrocodeine O-demethylation to dihydromorphine (DHM) is catalyzed by the polymorphic CYP2D6....

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Identifiers

PMID: 7586928
DOI: 10.1016/0009-9236(95)90049-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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