Molecular mechanisms of genetic polymorphisms of drug metabolism.

doi:10.1146/annurev.pharmtox.37.1.269

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Article

Molecular mechanisms of genetic polymorphisms of drug metabolism.

Annual review of pharmacology and toxicology - 1 Jan 1997

Meyer U A, Zanger U M

Abstract excerpt

One of the major causes of interindividual variation of drug effects is genetic variation of drug metabolism. Genetic polymorphisms of drug-metabolizing enzymes give rise to distinct subgroups in the population that differ in their ability to perform certain drug biotransformation reactions. Poly...

Topics

Acetylation
Alleles
Animals
Arylamine N-Acetyltransferase
Debrisoquin
Ethnicity
Gene Frequency
Humans
Liver
Mephenytoin
Mutation
Pharmaceutical Preparations
Polymorphism, Genetic
Sparteine

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