Article
Relationship between antipyrine metabolism and acetylation phenotype in health and chronic liver diseases.
Journal of clinical pharmacology - 1 Jun 1995
el-Yazigi A, Raines D A, Wahab F A, Sieck J O, Ernst P, Ali H, Dossing M
Abstract excerpt
The authors examined the activity of N-acetyltransferase and that of microsomal P-450 isoenzymes in health and hepatic disease state by determining the acetylation phenotype and the total (CLAP) and metabolic clearances of antipyrine to form norantipyrine or N-demethylantipyrine (MCLnora), 3-hydr...
Topics
- Acetylation
- Adult
- Antipyrine
- Arylamine N-Acetyltransferase
- Chronic Disease
- Cytochrome P-450 Enzyme System
- Female
- Health Status
- Humans
- Liver Diseases
- Male
- Metabolic Clearance Rate
- Microsomes, Liver
- Middle Aged
- Phenotype