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Article

Relationship between antipyrine metabolism and acetylation phenotype in health and chronic liver diseases.

Journal of clinical pharmacology - 1 Jun 1995

el-Yazigi A, Raines D A, Wahab F A, Sieck J O, Ernst P, Ali H, Dossing M

Abstract excerpt

The authors examined the activity of N-acetyltransferase and that of microsomal P-450 isoenzymes in health and hepatic disease state by determining the acetylation phenotype and the total (CLAP) and metabolic clearances of antipyrine to form norantipyrine or N-demethylantipyrine (MCLnora), 3-hydroxymethylantipyrine (MCLhma), and 4-hydroxyantipyrine (MCLha) in 21 healthy subjects and in 33 patients with chronic...

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Share to Acetylation
Share to Arylamine N-Acetyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Cytochrome P-450 Enzyme System

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Share to Metabolic Clearance Rate

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Source

Identifiers

PMID: 7665722
DOI: 10.1002/j.1552-4604.1995.tb05019.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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