Article
High loading of polygenic risk in cases with chronic schizophrenia.
Molecular psychiatry - 1 Jul 2016
Meier S M, Agerbo E, Maier R, Pedersen C B, Lang M, Grove J, Hollegaard M V, Demontis D, Trabjerg B B, Hjorthøj C, Ripke S, Degenhardt F, Nöthen M M, Rujescu D, Maier W, Werge T, Mors O, Hougaard D M, Børglum A D, Wray N R, Rietschel M, Nordentoft M, Mortensen P B, Mattheisen M
Abstract excerpt
Genomic risk profile scores (GRPSs) have been shown to predict case-control status of schizophrenia (SCZ), albeit with varying sensitivity and specificity. The extent to which this variability in prediction accuracy is related to differences in sampling strategies is unknown. Danish population-based registers and Neonatal Biobanks were used to identify two independent incident data sets (denoted target and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.