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Article

Schizophrenia Genetics Modulates Clinical Depressive Features.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2026

Serretti Alessandro, Souery Daniel, Kasper Siegfried, Zohar Joseph, Montgomery Stuart, Ferentinos Panagiotis, Rujescu Dan, Ferri Raffaele, Fanelli Giuseppe, Fabbri Chiara, Zanardi Raffaella, Benedetti Francesco, Baune Bernhard T, Mendlewicz Julien

Abstract excerpt

Schizophrenia (SCZ) genetic liability, quantified by polygenic scores (PGS), may influence clinical phenotypes in major depressive disorder (MDD). We investigated the effect of the SCZ-PGS derived from the latest SCZ genome-wide association study (GWAS) on MDD symptom severity, comorbidities, and treatment outcomes. The study included 1060 adults diagnosed with MDD from the GSRD sample, with replication in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41115750
DOI: 10.1002/ajmg.b.33066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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