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Article

Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2015

Wu Qing, Zhang Jiaojiao, Koh Wonshill, Yu Qingming, Zhu Xiaojun, Amsterdam Adam, Davis George E, Arnaout M Amin, Xiong Jing-Wei

Abstract excerpt

Talin (tln) binds and activates integrins to couple extracellular matrix-bound integrins to the cytoskeleton; however, its role in heart development is not well characterized. We identified the defective gene and the resulting cardiovascular phenotypes in zebrafish tln1(fl02k) mutants. The ethylnitrosourea-induced fl02k mutant showed heart failure, brain hemorrhage, and diminished cardiac and vessel lumens at 52...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26310270
DOI: 10.1096/fj.15-273409
PMCID: PMC4653057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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