Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart.

Circulation research - 4 Aug 2006

Rottbauer Wolfgang, Wessels Georgia, Dahme Tillman, Just Steffen, Trano Nicole, Hassel David, Burns Charles Geoffrey, Katus Hugo A, Fishman Mark C

Abstract excerpt

Although it is well known that mutations in the cardiac regulatory myosin light chain-2 (mlc-2) gene cause hypertrophic cardiomyopathy, the precise in vivo structural and functional roles of MLC-2 in the heart are only poorly understood. We have isolated a mutation in zebrafish, tell tale heart (tel(m225)), which selectively perturbs contractility of the embryonic heart. By positional cloning, we identified tel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Myosins
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Atria

Share to Heart Ventricles

Share to Muscle Development

Share to Myocardial Contraction

Share to Myosin Light Chains

Source

Identifiers

PMID: 16809551
DOI: 10.1161/01.RES.0000234807.16034.fe

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart.PMID 16809551Read ↗

A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heartSemantic proximity Read ↗

Expression of cardiac myosin light chain 2 during embryonic heart development in medaka fish, Oryzias latipes, and phylogenetic relationship with other myosin light chains.Semantic proximity Read ↗

Cardiac troponin T is essential in sarcomere assembly and cardiac contractility.Semantic proximity Read ↗

RBPMS2 is a conserved regulator of alternative splicing that promotes myofibrillar organization and optimal calcium handling in cardiomyocytesSemantic proximity Read ↗

Functions of myosin light chain-2 (MYL2) in cardiac muscle and diseaseSemantic proximity Read ↗

Lem2 is essential for cardiac development by maintaining nuclear integritySemantic proximity Read ↗

Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms.Semantic proximity Read ↗

Tropomyosin 1: Multiple roles in the developing heart and in the formation of congenital heart defects.Semantic proximity Read ↗

Identification of <i>MYOM2</i> as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot and its functional evaluation in the <i>Drosophila</i> heartSemantic proximity Read ↗

The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis.Semantic proximity Read ↗

Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos.Semantic proximity Read ↗

Lem2 is essential for cardiac development by maintaining nuclear integrity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.