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Article

Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish.

PloS one - 1 Jan 2016

Just Steffen, Raphel Linda, Berger Ina M, Bühler Anja, Keßler Mirjam, Rottbauer Wolfgang

Abstract excerpt

The molecular mechanisms that regulate cardiomyocyte proliferation during embryonic heart growth are not completely deciphered yet. In a forward genetic N-ethyl-N-nitrosourea (ENU) mutagenesis screen, we identified the recessive embryonic-lethal zebrafish mutant line weiches herz (whz). Homozygous mutant whz embryos display impaired heart growth due to diminished embryonic cardiomyocyte proliferation resulting in...

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Share to Gene Expression Regulation, Developmental
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27907103
DOI: 10.1371/journal.pone.0167306
PMCID: PMC5132222

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Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish.PMID 27907103Read ↗

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Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial ExpansionSemantic proximity Read ↗

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Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.Semantic proximity Read ↗

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