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Article

Endothelial deletion of Wt1 disrupts coronary angiogenesis and myocardium development

28 Feb 2023

Abstract excerpt

Wt1 encodes a zinc finger protein that is crucial for epicardium development. Although WT1 is also expressed in coronary endothelial cells (ECs), the abnormal heart development observed in Wt1 knockout mice is mainly attributed to its functions in the epicardium. Here, we have generated an inducible endothelial-specific Wt1 knockout mouse model (Wt1KOΔEC). Deletion of Wt1 in ECs during coronary plexus formation...

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PMID: 36852644
DOI: 10.1242/dev.201147

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