Article
Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity.
Disease models & mechanisms - 1 Jan 2011
Gjini Evisa, Hekking Liesbeth H, Küchler Axel, Saharinen Pipsa, Wienholds Erno, Post Jan-Andries, Alitalo Kari, Schulte-Merker Stefan
Abstract excerpt
Tie-2 is a member of the receptor tyrosine kinase family and is required for vascular remodeling and maintenance of mammalian vessel integrity. A number of mutations in the human TIE2 gene have been identified in patients suffering from cutaneomucosal venous malformations and ventricular septal defects. How exactly Tie-2 signaling pathways play different roles in both vascular development and vascular stability...
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