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Article

Tie1 regulates zebrafish cardiac morphogenesis through Tolloid-like 1 expression.

Developmental biology - 1 Jan 2021

Carlantoni Claudia, Allanki Srinivas, Kontarakis Zacharias, Rossi Andrea, Piesker Janett, Günther Stefan, Stainier Didier Y R

Abstract excerpt

Tie1 is a receptor tyrosine kinase expressed in endothelial cells, where it modulates Angiopoietin/Tie2 signaling. Previous studies have shown that mouse Tie1 mutants exhibit severe cardiovascular defects; however, much remains to be learned about the role of Tie1, especially during cardiac development. To further understand Tie1 function, we generated a zebrafish tie1 mutant line. Homozygous mutant embryos...

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Source

Identifiers

PMID: 32971120
DOI: 10.1016/j.ydbio.2020.09.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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