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Article

Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding.

Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2015

Webb Christopher J, Zakian Virginia A

Abstract excerpt

The stem terminus element (STE), which was discovered 13 y ago in human telomerase RNA, is required for telomerase activity, yet its mode of action is unknown. We report that the Schizosaccharomyces pombe telomerase RNA, TER1 (telomerase RNA 1), also contains a STE, which is essential for telomere maintenance. Cells expressing a partial loss-of-function TER1 STE allele maintained short stable telomeres by a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26305931
DOI: 10.1073/pnas.1503157112
PMCID: PMC4568702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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