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Article

The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity.

Nucleic acids research - 15 Jul 2003

Huard Sylvain, Moriarty Tara J, Autexier Chantal

Abstract excerpt

The catalytic subunit of telomerase (TERT) contains conserved reverse transcriptase-like motifs but N- and C-terminal regions unique to telomerases. Despite weak sequence conservation, the C terminus of TERTs from various organisms has been implicated in telomerase-specific functions, including telomerase activity, functional multimerization with other TERT molecules, enzyme processivity and telomere length...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12853623
DOI: 10.1093/nar/gkg437
PMCID: PMC165952

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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