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Article

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2014

Yu Tai-Yuan, Kao Yu-wen, Lin Jing-Jer

Abstract excerpt

In human somatic cells or yeast cells lacking telomerase, telomeres are shortened upon each cell division. This gradual shortening of telomeres eventually leads to senescence. However, a small population of telomerase-deficient cells can survive by bypassing senescence through the activation of alternative recombination pathways to maintain their telomeres. Although genes involved in telomere recombination have...

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Identifiers

PMID: 24550456
DOI: 10.1073/pnas.1307415111
PMCID: PMC3948247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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