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Article

Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 2000

Haering C H, Nakamura T M, Baumann P, Cech T R

Abstract excerpt

The chromosome end-replicating enzyme telomerase is composed of a template-containing RNA subunit, a reverse transcriptase (TERT), and additional proteins. The importance of conserved amino acid residues in Trt1p, the TERT of Schizosaccharomyces pombe, was tested. Mutation to alanine of the proposed catalytic aspartates in reverse transcriptase motifs A and C and of conserved amino acids in motifs 1 and B'...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10829083
DOI: 10.1073/pnas.130187397
PMCID: PMC18609

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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