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Article

Viral precursor protein P3 and its processed products perform discrete and essential functions in the poliovirus RNA replication complex.

Virology - 1 Nov 2015

Spear Allyn, Ogram Sushma A, Morasco B Joan, Smerage Lucia Eisner, Flanegan James B

Abstract excerpt

The differential use of protein precursors and their products is a key strategy used during poliovirus replication. To characterize the role of protein precursors during replication, we examined the complementation profiles of mutants that inhibited 3D polymerase or 3C-RNA binding activity. We showed that 3D entered the replication complex in the form of its precursor, P3 (or 3CD), and was cleaved to release...

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Identifiers

PMID: 26303005
DOI: 10.1016/j.virol.2015.07.018
PMCID: PMC4780368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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