Viral precursor protein P3 and its processed products perform discrete and essential functions in the poliovirus RNA replication complex.

doi:10.1016/j.virol.2015.07.018

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Article

Viral precursor protein P3 and its processed products perform discrete and essential functions in the poliovirus RNA replication complex.

Virology - 1 Nov 2015

Spear Allyn, Ogram Sushma A, Morasco B Joan, Smerage Lucia Eisner, Flanegan James B

Abstract excerpt

The differential use of protein precursors and their products is a key strategy used during poliovirus replication. To characterize the role of protein precursors during replication, we examined the complementation profiles of mutants that inhibited 3D polymerase or 3C-RNA binding activity. We showed that 3D entered the replication complex in the form of its precursor, P3 (or 3CD), and was cleaved to release...

Topics

Gene Order
Genetic Complementation Test
Models, Biological
Mutation
Poliovirus
Protein Binding
Protein Precursors
RNA, Viral
Viral Proteins
Virus Replication

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Identifiers

PMID: 26303005
DOI: 10.1016/j.virol.2015.07.018
PMCID: PMC4780368

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