Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inefficient complementation activity of poliovirus 2C and 3D proteins for rescue of lethal mutations.

Journal of virology - 1 Jul 1995

Teterina N L, Zhou W D, Cho M W, Ehrenfeld E

Abstract excerpt

Poliovirus (PV) 2C protein is a nonstructural polypeptide involved in viral RNA replication, whose biochemical activity(ies) in this process has not been defined. By using site-directed mutagenesis, it was shown previously that disruption of nucleotide-binding motifs present in this protein abolished viral RNA synthesis (C. Mirzayan and E. Wimmer, Virology 189:547-555, 1992; N. L. Teterina, K. M. Kean, E....

Topics

Amino Acid Sequence
Carrier Proteins
Genome, Viral
Molecular Sequence Data
Mutation
Poliovirus
RNA, Viral
RNA-Dependent RNA Polymerase
Viral Nonstructural Proteins
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 7769684
DOI: 10.1128/JVI.69.7.4245-4254.1995
PMCID: PMC189162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7769684-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inefficient complementation activity of poliovirus 2C and 3D proteins for rescue of lethal mutations.PMID 7769684Read ↗

Analysis of the functional significance of amino acid residues in the putative NTP-binding pattern of the poliovirus 2C protein.Semantic proximity Read ↗

An efficient trans complementation system for in vivo replication of defective poliovirus mutants.Semantic proximity Read ↗

Efficient Rescue of Hepatitis C Virus RNA Replication by trans -Complementation with Nonstructural Protein 5ASemantic proximity Read ↗

Viral precursor protein P3 and its processed products perform discrete and essential functions in the poliovirus RNA replication complex.Semantic proximity Read ↗

Complementation Analysis of the Flavivirus Kunjin NS3 and NS5 Proteins Defines the Minimal Regions Essential for Formation of a Replication Complex and Shows a Requirement of NS3 in cis for Virus AssemblySemantic proximity Read ↗

Intragenomic complementation of a 3AB mutant in dicistronic polioviruses.Semantic proximity Read ↗

Alanine scanning of poliovirus 2CATPase reveals new genetic evidence that capsid protein/2CATPase interactions are essential for morphogenesis.Semantic proximity Read ↗

Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways.Semantic proximity Read ↗

Successful propagation of flavivirus infectious cDNAs by a novel method to reduce the cryptic bacterial promoter activity of virus genomes.Semantic proximity Read ↗

An authentic 3' noncoding region is necessary for efficient poliovirus replication.Semantic proximity Read ↗

An intragenic revertant of a poliovirus 2C mutant has an uncoating defect.Semantic proximity Read ↗

Complementation of a deletion in the rubella virus p150 nonstructural protein by the viral capsid protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.