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Article

Inefficient complementation activity of poliovirus 2C and 3D proteins for rescue of lethal mutations.

Journal of virology - 1 Jul 1995

Teterina N L, Zhou W D, Cho M W, Ehrenfeld E

Abstract excerpt

Poliovirus (PV) 2C protein is a nonstructural polypeptide involved in viral RNA replication, whose biochemical activity(ies) in this process has not been defined. By using site-directed mutagenesis, it was shown previously that disruption of nucleotide-binding motifs present in this protein abolished viral RNA synthesis (C. Mirzayan and E. Wimmer, Virology 189:547-555, 1992; N. L. Teterina, K. M. Kean, E....

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Identifiers

PMID: 7769684
DOI: 10.1128/JVI.69.7.4245-4254.1995
PMCID: PMC189162

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