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Functional advantages of triplication of the 3B coding region of the FMDV genome

23 Nov 2020

Abstract excerpt

For gene duplication to be maintained, particularly in the small genomes of RNA viruses, this should offer some advantages. We have investigated the functions of a small protein termed VPg or 3B, which acts as a primer in the replication of foot-and-mouth disease virus (FMDV). Many related picornaviruses encode a single copy but uniquely the FMDV genome includes three (nonidentical) copies of the 3B coding...

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PMID: 33230899
DOI: 10.1096/fj.202001473rr

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