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Article

An efficient trans complementation system for in vivo replication of defective poliovirus mutants.

Journal of virology - 23 Jul 2024

Arita Minetaro

Abstract excerpt

The picornavirus genome encodes a large, single polyprotein that is processed by viral proteases to form an active replication complex. The replication complex is formed with the viral genome, host proteins, and viral proteins that are produced/translated directly from each of the viral genomes (viral proteins provided in cis). Efficient complementation in vivo of replication complex formation by viral proteins...

Topics

Poliovirus
Virus Replication
Humans
Viral Proteins
HEK293 Cells
Mutation
Genetic Complementation Test
Polyproteins
Cysteine Endopeptidases
3C Viral Proteases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38837378
DOI: 10.1128/jvi.00523-24
PMCID: PMC11265389

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