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Article

Enhanced Recognition of HIV-1 Cryptic Epitopes Restricted by HLA Class I Alleles Associated With a Favorable Clinical Outcome.

Journal of acquired immune deficiency syndromes (1999) - 1 Sept 2015

Bansal Anju, Mann Tiffanie, Sterrett Sarah, Peng Binghao J, Bet Anne, Carlson Jonathan M, Goepfert Paul A

Abstract excerpt

BACKGROUND: Cryptic epitopes (CEs) are peptides derived from the translation of 1 or more of the 5 alternative reading frames (ARFs; 2 sense and 3 antisense) of genes. Here, we compared response rates to HIV-1-specific CE predicted to be restricted by HLA-I alleles associated with protection against disease progression to those without any such association. METHODS: Peptides (9mer to 11mer) were designed based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26322665
DOI: 10.1097/QAI.0000000000000700
PMCID: PMC4556167

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