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Article

The study of MED12 gene mutations in uterine leiomyomas from Iranian patients.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2016

Sadeghi Samaneh, Khorrami Mandana, Amin-Beidokhti Mona, Abbasi Maryam, Kamalian Zeeba, Irani Shiva, Omrani Mirdavood, Azmoodeh Ozra, Mirfakhraie Reza

Abstract excerpt

Uterine leiomyomas are the most common gynecologic benign tumors of the female genital tract that cause a variety of health problems including, abnormal menstrual bleeding, pelvic pain, placenta displacement, premature labor, and miscarriages. Recently, studies showed that recurrent somatic mutations in MED12 exon 2 are the major cause of uterine leiomyomas in different ethnic groups. In order to validate these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26298726
DOI: 10.1007/s13277-015-3943-8

Genes

MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The study of MED12 gene mutations in uterine leiomyomas from Iranian patients.PMID 26298726Read ↗

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Missense mutations in exon 2 of the MED12 gene are involved in IGF-2 overexpression in uterine leiomyomaSemantic proximity Read ↗

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