Expanded Somatic Mutation Spectrum of MED12 Gene in Uterine Leiomyomas of Saudi Arabian Women

Abstract excerpt

MED12, a subunit of mediator complex genes is known to harbor genetic mutations, mostly in exon 2, causal to the genesis of uterine leiomyomas among Caucasian, African American and Asian women. However, the precise relationship between genetic mutations versus protein or disease phenotype is not well explained. Therefore, we sought to replicate the MED12 mutation frequency in leiomyomas of Saudi Arabian women,...

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