Genetic-Epigenetic Interactions in Uterine Leiomyomas: MED12 Mutations as Predictors of Aberrant DNA Methylation.

doi:10.3390/genes17080877

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Genetic-Epigenetic Interactions in Uterine Leiomyomas: MED12 Mutations as Predictors of Aberrant DNA Methylation.

Genes - 28 Jul 2026

Kazmi Tayyaba, Nangrejo Ruqaya, Abbas Eraj, Waris Nazish, Siddiqui Iftikhar Ahmed, Rehman Rehana, Laurance-Young Paul

Abstract excerpt

Objective: The study was conducted to investigate the frequency of MED12 gene (rs5030619) mutations and to evaluate DNA methylation patterns in uterine leiomyomas among women at a tertiary care hospital in Karachi, Pakistan. Methods: In this cross-sectional study, 200 women with uterine fibroids and 50 controls were recruited from tertiary care hospitals after ethical approval. Baseline data and history were...

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PMID: 42650070
DOI: 10.3390/genes17080877
PMCID: PMC13512488

Genes

MED12

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