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Article

Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers.

Neurobiology of disease - 1 Nov 2015

Politis Marios, Lahiri Nayana, Niccolini Flavia, Su Paul, Wu Kit, Giannetti Paolo, Scahill Rachael I, Turkheimer Federico E, Tabrizi Sarah J, Piccini Paola

Abstract excerpt

Previous studies have shown activation of the immune system and altered immune response in Huntington's disease (HD) gene carriers. Here, we hypothesized that peripheral and central immune responses could be concurrent pathophysiological events and represent a global innate immune response to the toxic effects of mutant huntingtin in HD gene carriers. We sought to investigate our hypothesis using [(11)C]PK11195...

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Identifiers

PMID: 26297319
DOI: 10.1016/j.nbd.2015.08.011

Genes

TSPO
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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