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Article

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors.

Nature neuroscience - 1 Apr 2014

Crotti Andrea, Benner Christopher, Kerman Bilal E, Gosselin David, Lagier-Tourenne Clotilde, Zuccato Chiara, Cattaneo Elena, Gage Fred H, Cleveland Don W, Glass Christopher K

Abstract excerpt

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an extended polyglutamine repeat in the N terminus of the Huntingtin protein (HTT). Reactive microglia and elevated cytokine levels are observed in the brains of HD patients, but the extent to which neuroinflammation results from extrinsic or cell-autonomous mechanisms in microglia is unknown. Using genome-wide approaches, we found that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24584051
DOI: 10.1038/nn.3668
PMCID: PMC4113004

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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