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Hypothalamic involvement in Huntington's disease: an in vivo PET study

21 Jun 2008

Abstract excerpt

Recent studies have shown alterations in metabolism, sleep and circadian rhythms as well as in several neuropeptides derived from the hypothalamic-pituitary axis in Huntington's disease patients; however, the pathology underlying these abnormalities is not known. Our aim was to assess in vivo D(2) receptor's loss/dysfunction and increases in microglial activation in the hypothalamus of symptomatic Huntington's...

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PMID: 18829696
DOI: 10.1093/brain/awn244

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