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Article

Microglia-mediated neuron death requires TNF and is exacerbated by mutant Huntingtin.

Pharmacological research - 1 Nov 2024

Young Alexander P, Denovan-Wright Eileen M

Abstract excerpt

Microglia, the resident immune cells of the brain, regulate the balance of inflammation in the central nervous system under healthy and pathogenic conditions. Huntington's disease (HD) is a chronic neurodegenerative disease characterized by activated microglia and elevated concentrations of pro-inflammatory cytokines within the brain. Chronic hyperactivation of microglia is associated with brain pathology and...

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Identifiers

PMID: 39362509
DOI: 10.1016/j.phrs.2024.107443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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