A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.

doi:10.1084/jem.20080178

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Article

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.

The Journal of experimental medicine - 4 Aug 2008

Björkqvist Maria, Wild Edward J, Thiele Jenny, Silvestroni Aurelio, Andre Ralph, Lahiri Nayana, Raibon Elsa, Lee Richard V, Benn Caroline L, Soulet Denis, Magnusson Anna, Woodman Ben, Landles Christian, Pouladi Mahmoud A, Hayden Michael R, Khalili-Shirazi Azadeh, Lowdell Mark W, Brundin Patrik, Bates Gillian P, Leavitt Blair R, Möller Thomas, Tabrizi Sarah J

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral immune system and found widespread evidence of innate immune activation detectable in plasma throughout the course of HD. Interleukin 6 levels were increased in HD gene carriers with a mean of 16 years before the predicted onset of clinical symptoms. To our...

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PMID: 18625748
DOI: 10.1084/jem.20080178
PMCID: PMC2525598

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