Article

Mutant huntingtin protein alters the response of microglial cells to inflammatory stimuli

2019-02-15

Abstract excerpt

Huntington’s disease (HD) is a progressive neurodegenerative disease that affects the striatum and cerebral cortex. It is caused by a dominant CAG trinucleotide expansion in exon 1 of the HTT gene. Mutant huntingtin protein (mHtt) is expressed in neurons and immune cells. HD patients demonstrate altered blood cytokine profiles and altered responses of peripheral immune cells to inflammatory stimuli. However, the...

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Literature Corpus work: 098bc3b2-aefa-5859-93d1-0a384ea64012
DOI: 10.1101/550913

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